Reduced CSF orexin levels in rats and patients with systemic inflammation: a preliminary study.

ABSTRACT:

Objective

Sepsis is a lethal condition characterized by systemic inflammation and multiple organ failure; this condition was initially defined as systemic inflammatory response syndrome (SIRS) due to infection. We previously reported that the hypothalamic neuropeptide orexin improved survival in a murine model of sepsis by mainly acting in the medullary raphe nucleus through orexin type-2 receptors. We hypothesized that orexin treatment enhances recovery from sepsis by reversing the reduction in orexin levels in the cerebrospinal fluid (CSF). We recently reported a case in which CSF orexin levels were reduced in a patient with sepsis. Herein, we attempted to further investigate CSF orexin levels in rats and patients with systemic inflammation. This patient study was a single-center

SUBMITTER: Ogawa Y 

PROVIDER: S-EPMC9233848 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature