Genetic characterization of two G8P[8] rotavirus strains isolated in Guangzhou, China, in 2020/21: evidence of genome reassortment.

ABSTRACT:

Background

The G8 rotavirus genotype has been detected frequently in children in many countries and even became the predominant strain in sub-Saharan African countries, while there are currently no reports from China. In this study we described the genetic characteristics and evolutionary relationship between rotavirus strains from Guangzhou in China and the epidemic rotavirus strains derived from GenBank, 2020-2021.

Methods

Virus isolation and subsequent next-generation sequencing were performed for confirmed G8P[8] specimens. The genetic characteristics and evolutionary relationship were analyzed in comparison with epidemic rotavirus sequences obtained from GenBank.

Results

The two Guangzhou G8 strains were DS-1-like with the closest genetic distance to strains circ

SUBMITTER: Wang SJ 

PROVIDER: S-EPMC9238253 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature