Combining HbA_1c and glycated albumin improves detection of dysglycaemia in mixed-ancestry South Africans.

ABSTRACT:

Background

Combining HbA_1c with glycated albumin (GA) may improve detection of dysglycaemia. As BMI correlates positively with HbA_1c and negatively with GA, HbA_1c may be more effective in obese and GA in nonobese individuals.

Methods

To relate these findings to Africans, we assessed in 1274 South Africans living in CapeTown (male 26%; age 48±16y; BMI 28.7 kg/m² (range 15.6-73.8); obesity 39.9% and no prior diabetes history) the: (1) correlation of BMI with HbA_1c and GA, (2) ability of HbA_1c and GA separately and jointly, to detect OGTT-diagnosed dysglycaemia (diabetes plus prediabetes). Data collection took place between 2014 and 2016 in the City of Cape Town. Dysglycaemia was diagnosed by glucose criteria for

SUBMITTER: Kengne AP 

PROVIDER: S-EPMC9249545 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature