Ultrafast Tracking of Oxygen Dynamics During Proton FLASH.

ABSTRACT:

Purpose

Radiation therapy delivered at ultrafast dose rates, known as FLASH RT, has been shown to provide a therapeutic advantage compared with conventional radiation therapy by selectively protecting normal tissues. Radiochemical depletion of oxygen has been proposed to underpin the FLASH effect; however, experimental validation of this hypothesis has been lacking, in part owing to the inability to measure oxygenation at rates compatible with FLASH.

Methods and materials

We present a new variant of the phosphorescence quenching method for tracking oxygen dynamics with rates reaching up to ∼3.3 kHz. Using soluble Oxyphor probes we were able to resolve, both in vitro and in vivo, oxygen dynamics during the time of delivery of proton FLASH.

Results

In vitro in solutions

SUBMITTER: El Khatib M 

PROVIDER: S-EPMC9250619 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature