Ontology highlight
ABSTRACT:
SUBMITTER: Richter-Pechanska P
PROVIDER: S-EPMC9252914 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Richter-Pechańska Paulina P Kunz Joachim B JB Rausch Tobias T Erarslan-Uysal Büşra B Bornhauser Beat B Frismantas Viktoras V Assenov Yassen Y Zimmermann Martin M Happich Margit M von Knebel-Doeberitz Caroline C von Neuhoff Nils N Köhler Rolf R Stanulla Martin M Schrappe Martin M Cario Gunnar G Escherich Gabriele G Kirschner-Schwabe Renate R Eckert Cornelia C Avigad Smadar S Pfister Stefan M SM Muckenthaler Martina U MU Bourquin Jean-Pierre JP Korbel Jan O JO Kulozik Andreas E AE
Leukemia 20220518 7
The mechanisms underlying T-ALL relapse remain essentially unknown. Multilevel-omics in 38 matched pairs of initial and relapsed T-ALL revealed 18 (47%) type-1 (defined by being derived from the major ancestral clone) and 20 (53%) type-2 relapses (derived from a minor ancestral clone). In both types of relapse, we observed known and novel drivers of multidrug resistance including MDR1 and MVP, NT5C2 and JAK-STAT activators. Patients with type-1 relapses were specifically characterized by IL7R up ...[more]