Low Sperm Motility Is Determined by Abnormal Protein Modification during Epididymal Maturation.

ABSTRACT:

Purpose

During epididymal sperm maturation, spermatozoa acquire progressive motility through dynamic protein modifications. However, the relationship between sequential protein modifications during epididymal sperm maturation and sperm motility and fertility has not yet been investigated. This study investigated whether sequential changes in fertility-related protein expression including that of enolase 1 (ENO1), ubiquinol-cytochrome c reductase core protein 1 and 2 (UQCRC1 and UQCRC2), and voltage-dependent anion channel 2 (VDAC2) in spermatozoa during epididymal maturation are related to bovine sperm motility. Moreover, we found that mitochondrial metabolism is closely related to fertility-related proteins. Therefore, we investigated how the sequential modification of mitochondri

SUBMITTER: Park YJ 

PROVIDER: S-EPMC9253804 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature