A narrative review of research progress on the role of NLRP3 inflammasome in acne vulgaris.

ABSTRACT:

Background and objective

Acne vulgaris is a common skin disease around the world which affects the appearance of patients, as well as their physical and mental health. Cutibacterium acnes plays a vital role in the occurrence and development of acne vulgaris. Pattern recognition receptors (PRRs) are the first line of defense against external pathogens. The nucleotide oligomerization domain (NOD)-like receptor family pyrin containing 3 (NLRP3) inflammasome has recently been shown to contribute to the pathogenesis of acne vulgaris. The purpose of this review is to clarify the underlying mechanisms of NLRP3 inflammasome in the pathogenesis of acne vulgaris, and its potential as a therapeutic target for the condition.

Methods

The PubMed database was searched

SUBMITTER: Zhu W 

PROVIDER: S-EPMC9263782 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature