Moricizine prevents atrial fibrillation by late sodium current inhibition in atrial myocytes.

ABSTRACT:

Background

Enhanced late sodium current (INaL) is reportedly related to an increased risk of atrial fibrillation (AF). Moricizine, as a widely used anti-arrhythmia drug for suppressing ventricular tachycardia, has also been shown to prevent paroxysmal AF. However, the mechanism of its therapeutic effect remains poorly understood.

Methods

Angiotensin II (Ang II) was induced in C57Bl/6 mice (male wild-type) for 4 weeks to increase the susceptibility of AF, and acetylcholine-calcium chloride was used to induce AF. The whole-cell patch-clamp technique was used to detect INaL from isolated atrial myocytes. The expression of proteins in atrial of mice and HL-1 cells were examined by Western-blot.

Results

The results showed that moricizine significantly inhibited Ang II-medi

SUBMITTER: Zou T 

PROVIDER: S-EPMC9264100 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature