Synergistic Association between Plasma Aβ_1-42 and p-tau in Alzheimer's Disease but Not in Parkinson's Disease or Frontotemporal Dementia.

ABSTRACT: Beta-amyloid (Aβ_1-42) triggers the phosphorylation of tau protein in Alzheimer's disease (AD), but the relationship between phosphorylated tau (p-tau) and Aβ_1-42 in the blood is not elucidated. We investigated the association in individuals with AD (n = 62, including amnesic mild cognitive impairment and dementia), Parkinson's disease (n = 30), frontotemporal dementia (n = 25), and cognitively unimpaired controls (n = 41) using immunomagnetic reduction assays to measure plasma Aβ_1-42 and p-tau181 concentrations. Correlation and regression analyses were performed to examine the relation between plasma levels, demographic factors, and clinical severity. Both plasma Aβ_1-42 and p-tau concentrations were significantly highe

SUBMITTER: Chiu MJ 

PROVIDER: S-EPMC9278807 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature