Tocolysis with nifedipine versus atosiban and perinatal outcome: an individual participant data meta-analysis.

ABSTRACT:

Background

Worldwide, nifedipine and atosiban are the two most commonly used tocolytic agents for the treatment of threatened preterm birth. The aim of this study was to evaluate the effectiveness of nifedipine and atosiban in an individual participant data meta-analysis (IPDMA).

Methods

We investigated the occurrence of adverse neonatal outcomes in women with threatened preterm birth by performing an IPDMA, and sought to identify possible subgroups in which one treatment may be preferred. We searched PubMed, Embase, and Cochrane for trials comparing nifedipine and atosiban for treatment of threatened preterm birth between 24^0/7 and 34^0/7 weeks' gestational age. Primary outcome was a composite of perinatal mortality and neonatal morbidities including re

SUBMITTER: van Winden TMS 

PROVIDER: S-EPMC9284745 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature