Unknown

Dataset Information

0

Post-recovery COVID-19 and incident heart failure in the National COVID Cohort Collaborative (N3C) study.


ABSTRACT: Cardiac involvement has been noted in COVID-19 infection. However, the relationship between post-recovery COVID-19 and development of de novo heart failure has not been investigated in a large, nationally representative population. We examined post-recovery outcomes of 587,330 patients hospitalized in the United States (257,075 with COVID-19 and 330,255 without), using data from the National COVID Cohort Collaborative study. Patients hospitalized with COVID-19 were older (51 vs. 46 years), more often male (49% vs. 42%), and less often White (61% vs. 69%). Over a median follow up of 367 days, 10,979 incident heart failure events occurred. After adjustments, COVID-19 hospitalization was associated with a 45% higher hazard of incident heart failure (hazard ratio = 1.45; 95% confidence interval: 1.39-1.51), with more pronounced associations among patients who were younger (P-interaction = 0.003), White (P-interaction = 0.005), or who had established cardiovascular disease (P-interaction = 0.005). In conclusion, COVID-19 hospitalization is associated with increased risk of incident heart failure.

SUBMITTER: Salah HM 

PROVIDER: S-EPMC9284961 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Post-recovery COVID-19 and incident heart failure in the National COVID Cohort Collaborative (N3C) study.

Salah Husam M HM   Fudim Marat M   O'Neil Shawn T ST   Manna Amin A   Chute Christopher G CG   Caughey Melissa C MC  

Nature communications 20220715 1


Cardiac involvement has been noted in COVID-19 infection. However, the relationship between post-recovery COVID-19 and development of de novo heart failure has not been investigated in a large, nationally representative population. We examined post-recovery outcomes of 587,330 patients hospitalized in the United States (257,075 with COVID-19 and 330,255 without), using data from the National COVID Cohort Collaborative study. Patients hospitalized with COVID-19 were older (51 vs. 46 years), more  ...[more]

Similar Datasets

| S-EPMC7454687 | biostudies-literature
| S-EPMC8328064 | biostudies-literature
| S-EPMC9555705 | biostudies-literature
| S-EPMC10432357 | biostudies-literature
| S-EPMC9387155 | biostudies-literature
| S-EPMC9936475 | biostudies-literature
| S-EPMC10975285 | biostudies-literature
| S-EPMC11795369 | biostudies-literature
| S-EPMC10912146 | biostudies-literature
| S-EPMC9915827 | biostudies-literature