A pan-cancer analysis of thioredoxin-interacting protein as an immunological and prognostic biomarker

ABSTRACT:

Background

The critical role of thioredoxin-interacting protein (TXNIP) in cellular sulfhydryl redox homeostasis and inflammasome activation is already widely known, however, no pan-cancer analysis is currently available.

Methods

We thus first explored the potential roles of TXNIP across thirty-three tumors mainly based on The Cancer Genome Atlas and Gene Expression Omnibus datasets.

Results

TXNIP is lowly expressed in most cancers, and distinct associations exist between TXNIP expression and the prognosis of tumor patients. TXNIP expression was associated with tumor mutational burden, microsatellite instability, mismatch repair genes, tumor infiltrating immune cell abundance as well as cancer-associated fibroblasts. Moreover, ubiquitin mediated proteolysis, prot

SUBMITTER: Guo X 

PROVIDER: S-EPMC9288722 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature