The feeding behaviour of Amyotrophic Lateral Sclerosis mouse models is modulated by the Ca²⁺ -activated K_Ca 3.1 channels.

ABSTRACT:

Background and purpose

Amyotrophic lateral sclerosis (ALS) patients exhibit dysfunctional energy metabolism and weight loss, which is negatively correlated with survival, together with neuroinflammation. However, the possible contribution of neuroinflammation to deregulations of feeding behaviour in ALS has not been studied in detail. We here investigated if microglial K_Ca 3.1 is linked to hypothalamic neuroinflammation and affects feeding behaviours in ALS mouse models.

Experimental approach

hSOD1^G93A and TDP43^A315T mice were treated daily with 120 mg·kg^-1 of TRAM-34 or vehicle by intraperitoneal injection from the presymptomatic until the disease onset phase. Body weight and food intake were measured weekly. The later by weighing

SUBMITTER: Cocozza G 

PROVIDER: S-EPMC9293222 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature