Dataset Information

Optimal saturation recovery time for minimizing the underestimation of arterial input function in quantitative cardiac perfusion MRI.

ABSTRACT:

Purpose

The purpose of this study was to determine an optimal saturation-recovery time (TS) for minimizing the underestimation of arterial input function (AIF) in quantitative cardiac perfusion MRI without multiple gadolinium injections per subject.

Methods

We scanned 18 subjects (mean age = 59 ± 14 years, 9/9 males/females) to acquire resting perfusion data and 1 additional subject (age = 38 years, male) to obtain stress-rest perfusion data using a 5-fold accelerated pulse sequence with radial k-space sampling and applied k-space weighted image contrast (KWIC) filters on the same k-space data to retrospectively reconstruct five AIF images with effective TS ranging from 10 to 21.2 ms (2.8 ms steps). Undersampled images were reconstructed using a compressed sensing framework with temporal-total-variation and temporal-principal-component as 2 orthogonal sparsifying transforms. The image processing steps included, same motion correction across five different AIF images, signal normalization by the proton-density-weighted-image, signal-to-T₁ conversion using a Bloch equation, T₁ -to-gadolinium-concentration conversion assuming fast water exchange, T₂ * correction to the AIF, and gadolinium-concentration to myocardial blood flow (MBF) conversion based on a Fermi model.

Results

Among five TS values, the shortest TS (10 ms) produced significantly (P < 0.05) higher peak AIF and lower resting MBF (13.73 mM, 0.73 mL g^-1 min^-1 ) than 12.8 ms (11.24 mM, 0.89 mL g^-1 min^-1 ), 15.6 ms (9.56 mM, 1.05 mL g^-1 min^-1 ), 18.4 ms (8.55 mM, 1.17 mL g^-1 min^-1 ), and 21.2 ms (7.95 mM, 1.27 mL g^-1 min^-1 ). Similarly, shorter TS reduced underestimation of AIF (or overestimation of MBF) for both during stress and at rest, but this effect was canceled in myocardial-perfusion-reserve (MPR).

Conclusion

This study demonstrates that TS of 10 ms reduces the underestimation of AIF and, hence, the overestimation of MBF compared with longer TS values (12.8-21.2 ms).

SUBMITTER: Fan L

PROVIDER: S-EPMC9321550 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Optimal saturation recovery time for minimizing the underestimation of arterial input function in quantitative cardiac perfusion MRI.

Fan Lexiaozi L Hong Kyungpyo K Hsu Li-Yueh LY Carr James C JC Allen Bradley D BD Lee Daniel C DC Kim Daniel D

Magnetic resonance in medicine 20220404 2

<h4>Purpose</h4>The purpose of this study was to determine an optimal saturation-recovery time (TS) for minimizing the underestimation of arterial input function (AIF) in quantitative cardiac perfusion MRI without multiple gadolinium injections per subject.<h4>Methods</h4>We scanned 18 subjects (mean age = 59 ± 14 years, 9/9 males/females) to acquire resting perfusion data and 1 additional subject (age = 38 years, male) to obtain stress-rest perfusion data using a 5-fold accelerated pulse sequen ...[more]

PMID: 35377476

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Project description:BackgroundQuantitative transport mapping (QTM) of blood velocity, based on the transport equation has been demonstrated higher accuracy and sensitivity of perfusion quantification than the traditional Kety's method-based cerebral blood flow (CBF). This study aimed to investigate the associations between QTM velocity and cognitive function in Alzheimer's disease (AD) using multiple post-labeling delay arterial spin labeling (ASL) MRI.MethodsA total of 128 subjects (21 normal controls (NC), 80 patients with mild cognitive impairment (MCI), and 27 AD) were recruited prospectively. All participants underwent MRI examination and neuropsychological evaluation. QTM velocity and traditional CBF maps were computed from multiple delay ASL. Regional quantitative perfusion measurements were performed and compared to study group differences. We tested the hypothesis that cognition declines with reduced cerebral blood perfusion with consideration of age and gender effects.ResultsIn cortical gray matter (GM) and the hippocampus, QTM velocity and CBF showed decreased values in the AD group compared to NC and MCI groups; QTM velocity, but not CBF, showed a significant difference between MCI and NC groups. QTM velocity and CBF showed values decreasing with age; QTM velocity, but not CBF, showed a significant gender difference between male and female. QTM velocity and CBF in the hippocampus were positively correlated with cognition, including global cognition, memory, executive function, and language function.ConclusionThis study demonstrated an increased sensitivity of QTM velocity as compared with the traditional Kety's method-based CBF. Specifically, we observed only in QTM velocity, reduced perfusion velocity in GM and the hippocampus in MCI compared with NC. Both QTM velocity and CBF demonstrated a reduction in AD vs. controls. Decreased QTM velocity and CBF in the hippocampus were correlated with poor cognitive measures. These findings suggest QTM velocity as potential biomarker for early AD blood perfusion alterations and it could provide an avenue for early intervention of AD.

Dataset Information

Optimal saturation recovery time for minimizing the underestimation of arterial input function in quantitative cardiac perfusion MRI.

Purpose

Methods

Results

Conclusion

Publications

Optimal saturation recovery time for minimizing the underestimation of arterial input function in quantitative cardiac perfusion MRI.

Similar Datasets

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