Mild behavioral impairment is associated with progression to Alzheimer's disease: A clinicopathological study.

ABSTRACT:

Introduction

Mild behavioral impairment (MBI) is characterized by later-life emergence of neuropsychiatric symptoms. Investigating its relationship with progression to Alzheimer's disease (AD) would provide insight on its importance as a predictor of AD.

Methods

Cognitively normal participants (N = 11,372) from the National Alzheimer's Coordinating Center were stratified by MBI status, using the Neuropsychiatric Inventory-Questionnaire. We investigated whether MBI and its domains were predictors of progression to clinically-diagnosed AD. MBI as a predictor of progression to neuropathology-confirmed AD was also investigated in those with neuropathological data.

Results

Six percent (N = 671) of participants progressed to AD. MBI (N = 2765) was a significant predictor of

SUBMITTER: Ruthirakuhan M 

PROVIDER: S-EPMC9339594 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature