Multifunctional Magnetic CuS/Gd₂O₃ Nanoparticles for Fluorescence/Magnetic Resonance Bimodal Imaging-Guided Photothermal-Intensified Chemodynamic Synergetic Therapy of Targeted Tumors.

ABSTRACT: Chemodynamic therapy (CDT), which consumes endogenous hydrogen peroxide (H₂O₂) to generate reactive oxygen species (ROS) and causes oxidative damage to tumor cells, shows tremendous promise for advanced cancer treatment. However, the rate of ROS generation based on the Fenton reaction is prone to being restricted by inadequate H₂O₂ and unattainable acidity in the hypoxic tumor microenvironment. We herein report a multifunctional nanoprobe (BCGCR) integrating bimodal imaging and photothermal-enhanced CDT of the targeted tumor, which is produced by covalent conjugation of bovine serum albumin-stabilized CuS/Gd₂O₃ nanoparticles (NPs) with the Cy5.5 fluorophore and the tumor-targeting ligand RGD. BCGCR exhibits intense near-infr

SUBMITTER: Luo M 

PROVIDER: S-EPMC9354791 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature