No bidirectional relationship between depression and periodontitis: A genetic correlation and Mendelian randomization study.

ABSTRACT:

Background

Observational and in-vivo research suggested a bidirectional relationship between depression and periodontitis. We estimated the genetic correlation and examined directionality of causation.

Methods

The study used summary statistics from published genome wide association studies, with sample sizes ranging from 45,563 to 797,563 individuals of European ancestry. We performed linkage disequilibrium score regression (LDSC) to estimate global correlation and used Heritability Estimation from Summary Statistics (ρ-HESS) to further examine local genetic correlation. Latent Heritable Confounder Mendelian randomization (LHC-MR), Causal Analysis using Summary Effect estimates (CAUSE), and conventional MR approaches assessed bidirectional causation.

Results

LD

SUBMITTER: Nolde M 

PROVIDER: S-EPMC9355660 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature