Placental proteins with predicted roles in fetal development decrease in premature infants.

ABSTRACT:

Background

Emerging evidence from animal experiments indicate that factors secreted by the placenta are critical for normal fetal organ development. Our objective was to characterize the umbilical vein and artery proteome in preterm infants and identify proteins that decrease in the neonatal circulation following delivery.

Methods

Cord blood at delivery and neonatal blood at 48-72 h of life was collected in 25 preterm infants. Plasma protein abundance was determined using the SomaLogic platform.

Results

When comparing protein levels of umbilical venous to arterial cord blood, 434 proteins were significantly higher indicating placental secretion into the fetal circulation. Moreover, when comparing neonatal blood to umbilical vein levels, 142 proteins were significantly

SUBMITTER: Schreiner C 

PROVIDER: S-EPMC9357234 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature