FoxP3⁺ CD8 T-cells in acute HIV infection and following early antiretroviral therapy initiation.

ABSTRACT:

Objectives

Besides CD4 regulatory T-cells (Tregs), immunosuppressor FoxP3⁺ CD8 T-cells are emerging as an important subset of Tregs, which contribute to immune dysfunction and disease progression in HIV infection. However, FoxP3⁺ CD8 T-cell dynamics in acute HIV infection and following early antiretroviral therapy (ART) initiation remain understudied.

Methods

Subsets of FoxP3⁺ CD8 T-cells were characterized both prospectively and cross-sectionally in PBMCs from untreated acute (n=26) and chronic (n=10) HIV-infected individuals, early ART-treated in acute infection (n=10, median of ART initiation: 5.5 months post-infection), ART-treated in chronic infection (n=10), elite controllers (n=18), and HIV-uninfected controls (n=21).

Results

Ac

SUBMITTER: Yero A 

PROVIDER: S-EPMC9372390 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature