Ontology highlight
ABSTRACT:
SUBMITTER: Cui C
PROVIDER: S-EPMC9372771 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Cui Chuanlong C Wu Changgong C Shu Ping P Liu Tong T Li Hong H Beuve Annie A
Redox biology 20220802
Soluble guanylyl cyclase (GC1) is an α/β heterodimer producing cGMP when stimulated by nitric oxide (NO). The NO-GC1-cGMP pathway is essential for cardiovascular homeostasis but is disrupted by oxidative stress, which causes GC1 desensitization to NO by heme oxidation and S-nitrosation (SNO) of specific cysteines. We discovered that under these conditions, GC1-α subunit increases cellular S-nitrosation via transfer of nitrosothiols to other proteins (transnitrosation) in cardiac and smooth muscl ...[more]