Bioinformatics analysis of mRNA profiles and identification of microRNA-mRNA network in CD4⁺ T cells in seasonal allergic rhinitis.

ABSTRACT:

Objective

We aimed to discover potential circulating genes and non-coding molecules (micro RNA [miRNA] and circular RNA [circRNA]) in CD4⁺ T cells in relation to seasonal allergic rhinitis (SAR).

Methods

Microarray data of GSE50223 were obtained from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) during and outside the pollen season were analyzed using R software and by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway analyses. The protein-protein interactions, modules, miRNAs targeting DEGs, merged miRNA-DEG networks, and circRNAs targeted with miRNAs were further analyzed.

Results

We identified 211 DEGs during the pollen season and eight DEGs outside the season, of which only MMP12, NR4A2, a

SUBMITTER: Jin P 

PROVIDER: S-EPMC9373143 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature