High expression of fibroblast-activating protein is a prognostic marker in non-small cell lung carcinoma.

ABSTRACT:

Background

Fibroblast-activating protein (FAP) is expressed in cancer-associated fibroblasts (CAFs) in many human carcinomas and in some types of carcinoma cells. Here, we examined the proportion of FAP protein expression in non-small cell lung carcinoma (NSCLC) and investigated the correlation of FAP expression with clinicopathological background.

Methods

In total, 344 NSCLC tissues were examined. Tissue microarrays were constructed, and FAP expression was analyzed using immunohistochemistry. The status of FAP expression in tumor cells and CAFs was correlated with clinicopathological background, molecular features, and patient outcomes.

Results

A total of 280 patients (81.4%) had low FAP expression, and 64 patients (18.6%) had high FAP expression in tumor cells. In C

SUBMITTER: Yanagawa N 

PROVIDER: S-EPMC9376177 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature