Control of exploration, motor coordination and amphetamine sensitization by cannabinoid CB₁ receptors expressed in medium spiny neurons.

ABSTRACT: Activation of cannabinoid 1 receptors (CB₁ R) modulates multiple behaviours, including exploration, motor coordination and response to psychostimulants. It is known that CB₁ R expressed by either excitatory or inhibitory neurons mediates different behavioural responses to CB₁ R activation, yet the involvement of CB₁ R expressed by medium spiny neurons (MSNs), the neuronal subpopulation that expresses the highest level of CB₁ R in the CNS, remains unknown. We report a new genetically modified mouse line that expresses functional CB₁ R in MSN on a CB₁ R knockout (KO) background (CB₁ R_(MSN) mice). The absence of cannabimimetic responses measured in CB₁ R KO mice was not rescued in CB<

SUBMITTER: Bonm AV 

PROVIDER: S-EPMC9377695 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature