Changes in Sex Steroids and Enteric Peptides After Sleeve Gastrectomy in Youth in Relation to Changes in Bone Parameters.

ABSTRACT:

Context

Sleeve gastrectomy (SG) improves metabolic endpoints but is associated with impaired bone outcomes.

Objective

To determine mechanisms contributing to impaired bone health in youth following SG.

Methods

12-month longitudinal observational study in a multidisciplinary tertiary-care hospital, including 64 youth 13-25 years old with moderate-to-severe obesity (51 females); 30 underwent SG and 34 were nonsurgical (NS) controls. SG was undertaken after a combined decision-making process between treatment team and patient. The main outcome measures were fasting blood for enteric peptides, sex steroids, sclerostin, and bone turnover markers (N-terminal propeptide of type 1 procollagen [P1NP] and C-terminal cross-linking telopeptide [CTX]); dual-energy X-ray absorptiom

SUBMITTER: Nimmala S 

PROVIDER: S-EPMC9387701 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature