High PEEP Levels during CPR Improve Ventilation without Deleterious Haemodynamic Effects in Pigs.

ABSTRACT:

Background

Invasive ventilation during cardiopulmonary resuscitation (CPR) is very complex due to unique thoracic pressure conditions. Current guidelines do not provide specific recommendations for ventilation during ongoing chest compressions regarding positive end-expiratory pressure (PEEP). This trial examines the cardiopulmonary effects of PEEP application during CPR.

Methods

Forty-two German landrace pigs were anaesthetised, instrumented, and randomised into six intervention groups. Three PEEP levels (0, 8, and 16 mbar) were compared in high standard and ultralow tidal volume ventilation. After the induction of ventricular fibrillation, mechanical chest compressions and ventilation were initiated and maintained for thirty minutes. Blood gases, ventilation/perfusion rati

SUBMITTER: Renz M 

PROVIDER: S-EPMC9410261 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature