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Different cardiovascular risk factors are related to distinct white matter hyperintensity MRI phenotypes in older adults.


ABSTRACT: The underlying mechanisms of the association between cardiovascular risk factors and a higher white matter hyperintensity (WMH) burden are unknown. We investigated the association between cardiovascular risk factors and advanced WMH markers in 155 non-demented older adults (mean age: 71 ± 5 years). The association between cardiovascular risk factors and quantitative MRI-based WMH shape and volume markers were examined using linear regression analysis. Presence of hypertension was associated with a more irregular shape of periventricular/confluent WMH (convexity (B (95 % CI)): -0.12 (-0.22--0.03); concavity index: 0.06 (0.02-0.11)), but not with total WMH volume (0.22 (-0.15-0.59)). Presence of diabetes was associated with deep WMH volume (0.89 (0.15-1.63)). Body mass index or hyperlipidemia showed no association with WMH markers. In conclusion, different cardiovascular risk factors seem to be related to a distinct pattern of WMH shape markers in non-demented older adults. These findings may suggest that different underlying cardiovascular pathological mechanisms lead to different WMH MRI phenotypes, which may be valuable for early detection of individuals at risk for stroke and dementia.

SUBMITTER: Keller JA 

PROVIDER: S-EPMC9421504 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Different cardiovascular risk factors are related to distinct white matter hyperintensity MRI phenotypes in older adults.

Keller Jasmin A JA   Kant Ilse M J IMJ   Slooter Arjen J C AJC   van Montfort Simone J T SJT   van Buchem Mark A MA   van Osch Matthias J P MJP   Hendrikse Jeroen J   de Bresser Jeroen J  

NeuroImage. Clinical 20220729


The underlying mechanisms of the association between cardiovascular risk factors and a higher white matter hyperintensity (WMH) burden are unknown. We investigated the association between cardiovascular risk factors and advanced WMH markers in 155 non-demented older adults (mean age: 71 ± 5 years). The association between cardiovascular risk factors and quantitative MRI-based WMH shape and volume markers were examined using linear regression analysis. Presence of hypertension was associated with  ...[more]

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