The Association Between Forkhead Box Class O3A Gene Polymorphism and Psoriasis and Its Relationship with Psoriasis Severity.

ABSTRACT:

Background

Psoriasis vulgaris is a chronic, relapsing, inflammatory disorder marked by an intensified immune response. The role of immunogenetics in psoriasis is still poorly understood; however, experts agree that its expression depends on proinflammatory cytokines.Forkhead box class O3A (FOXO3a), a transcription factor, plays a crucial role in intercellular regulation, oxidative stress, deoxyribonucleic acid (DNA) repair, and cell death.

Objective

The objective of this study was to investigate the role of FOXO3a genetic polymorphism as a risk factor for psoriasis vulgaris and assess its possible relationship with disease severity.

Methods

A comparative case-control study included 53 patients with psoriasis and 41 matched healthy controls. We measured serum FOXO3a le

SUBMITTER: Abd Elneam AI 

PROVIDER: S-EPMC9436227 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature