Progressive Decline in Estimated GFR in Patients With Sickle Cell Disease: An Observational Cohort Study.

ABSTRACT:

Rationale & objective

Progression of chronic kidney disease (CKD) in sickle cell disease (SCD) and its risk factors remain poorly defined. We identified characteristics associated with CKD as well as decline in estimated glomerular filtration rate (eGFR) and presence of proteinuria over time in adults with SCD.

Study design

Retrospective observational study.

Setting & participants

Patients with SCD 18 years or older in a single center from 2004 to 2013.

Predictors

Baseline clinical and laboratory measures, comorbid conditions, SCD-related complications, relevant treatments, and severity of genotypes defined as severe (homozygous SCD [HbSS]/sickle-β⁰-thalassemia [HbSβ⁰]) or mild (hemoglobin SC disease [HbSC]/sickle-β⁺-thalassemia

SUBMITTER: Derebail VK 

PROVIDER: S-EPMC9449709 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature