Insights from the IronTract challenge: Optimal methods for mapping brain pathways from multi-shell diffusion MRI.

ABSTRACT: Limitations in the accuracy of brain pathways reconstructed by diffusion MRI (dMRI) tractography have received considerable attention. While the technical advances spearheaded by the Human Connectome Project (HCP) led to significant improvements in dMRI data quality, it remains unclear how these data should be analyzed to maximize tractography accuracy. Over a period of two years, we have engaged the dMRI community in the IronTract Challenge, which aims to answer this question by leveraging a unique dataset. Macaque brains that have received both tracer injections and ex vivo dMRI at high spatial and angular resolution allow a comprehensive, quantitative assessment of tractography accuracy on state-of-the-art dMRI acquisition schemes. We find that, when analysis methods are carefully optim

SUBMITTER: Maffei C 

PROVIDER: S-EPMC9453851 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature