Novel Association between STAT3 Gene Variant and Vitiligo: A Case-Control Study.

ABSTRACT:

Background

Vitiligo is an autoimmune disorder involving inflammatory damage to melanocytes. STAT3 genetic variant (rs744166 T > C) increases inflammatory signaling via JAK/STAT pathway.

Aim

The purpose of this study was to check whether this translates into an association between vitiligo and STAT3 gene variant (rs744166 T > C).

Materials and methods

This is a case-control study. A total of 56 vitiligo patients and 90 healthy, age and gender-matched volunteers were recruited for the study. The STAT3 gene variant (rs744166 T > C) was genotyped using the restriction fragment length polymorphism method.

Results

The frequency of the minor allele 'C' was higher in vitiligo patients (72.3%) than in healthy volunteers (57.8%). The difference betwe

SUBMITTER: Venkatesh V 

PROVIDER: S-EPMC9455129 | biostudies-literature | 2022 Mar-Apr

REPOSITORIES: biostudies-literature