Dataset Information

Novel Association between STAT3 Gene Variant and Vitiligo: A Case-Control Study.

ABSTRACT:

Background

Vitiligo is an autoimmune disorder involving inflammatory damage to melanocytes. STAT3 genetic variant (rs744166 T > C) increases inflammatory signaling via JAK/STAT pathway.

Aim

The purpose of this study was to check whether this translates into an association between vitiligo and STAT3 gene variant (rs744166 T > C).

Materials and methods

This is a case-control study. A total of 56 vitiligo patients and 90 healthy, age and gender-matched volunteers were recruited for the study. The STAT3 gene variant (rs744166 T > C) was genotyped using the restriction fragment length polymorphism method.

Results

The frequency of the minor allele 'C' was higher in vitiligo patients (72.3%) than in healthy volunteers (57.8%). The difference between the two groups was statistically significant (P = 0.006; OR = 1.9 with 95% CI). The genotypic variant showed the highest association with vitiligo in the dominant model (P = 0.001).

Conclusion

This study shows that the STAT3 gene variant (rs744166 T > C) is associated with vitiligo. This observation underlines the importance of the JAK/STAT signaling pathway in vitiligo pathogenesis.

SUBMITTER: Venkatesh V

PROVIDER: S-EPMC9455129 | biostudies-literature | 2022 Mar-Apr

REPOSITORIES: biostudies-literature

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Publications

Novel Association between <i>STAT3</i> Gene Variant and Vitiligo: A Case-Control Study.

Venkatesh Vaibhav V Mendez Deena C DC Rajashekar T S TS Balakrishna Sharath S

Indian journal of dermatology 20220301 2

<h4>Background</h4>Vitiligo is an autoimmune disorder involving inflammatory damage to melanocytes. <i>STAT3</i> genetic variant (rs744166 T > C) increases inflammatory signaling via JAK/STAT pathway.<h4>Aim</h4>The purpose of this study was to check whether this translates into an association between vitiligo and <i>STAT3</i> gene variant (rs744166 T > C).<h4>Materials and methods</h4>This is a case-control study. A total of 56 vitiligo patients and 90 healthy, age and gender-matched volunteers ...[more]

PMID: 36092187

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