Nanoparticles reduce monocytes within the lungs to improve outcomes after influenza virus infection in aged mice.

ABSTRACT: Older people exhibit dysregulated innate immunity to respiratory viral infections, including influenza and SARS-CoV-2, and show an increase in morbidity and mortality. Nanoparticles are a potential practical therapeutic that could reduce exaggerated innate immune responses within the lungs during viral infection. However, such therapeutics have not been examined for effectiveness during respiratory viral infection, particular in aged hosts. Here, we employed a lethal model of influenza viral infection in vulnerable aged mice to examine the ability of biodegradable, cargo-free nanoparticles, designated ONP-302, to resolve innate immune dysfunction and improve outcomes during infection. We administered ONP-302 via i.v. injection to aged mice at day 3 after infection, when the hyperinflammato

SUBMITTER: Kelley WJ 

PROVIDER: S-EPMC9462478 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature