Dataset Information

Intrauterine interventions for women with two or more implantation failures: A systematic review and network meta-analysis.

ABSTRACT:

Objective

To compare the effectiveness of different intrauterine interventions for women with two or more unexplained implantation failures.

Design

A systematic review and network meta-analysis of randomized controlled trials (RCTs).

Patients

Women with two or more implantation failures undergoing fresh or frozen embryo transfer (ET).

Interventions

An electronic search of the following databases: Pubmed, Cochrane Central Register of Controlled Trials (CENTRAL), and Embase.

Main outcome measures

Clinical pregnancy, live birth/ongoing pregnancy, and miscarriage.

Results

We included 21 RCTs(3079 women) in the network meta-analysis. The network meta-analysis showed that compared with control treatment, platelet-rich plasma(PRP), peripheral blood mononuclear cells (PBMC), granulocyte colony-stimulating factor(G-CSF), human chorionic gonadotropin(HCG), and endometrial scratch(ES) significantly increased clinical pregnancy(OR 3.78, 95% CI 2.72 to 5.25; 2.79, 95% CI 1.75 to 4.45; 1.93, 95% CI 1.37 to 2.72; 1.80, 95% CI 1.18 to 2.72; 1.75, 95% CI 1.29 to 2.36, respectively). PRP ranked the highest in improving clinical pregnancy, followed by PBMC, G-CSF, HCG, and ES. Compared with control treatment, PRP, PBMC, and ES significantly increased live birth/ongoing pregnancy (OR 5.96, 95% CI 3.38 to 10.52; OR 2.55, 95% CI 1.27 to 5.11; OR 1.70, 95% CI 1.07 to 2.69, respectively). PRP ranked the highest in improving live birth/ongoing pregnancy, followed by PBMC, and ES.

Conclusions

PRP is the most effective intrauterine intervention in improving pregnancy outcome in women with two or more implantation failures.

SUBMITTER: Jin XH

PROVIDER: S-EPMC9464901 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Intrauterine interventions for women with two or more implantation failures: A systematic review and network meta-analysis.

Jin Xin Hang XH Li Yang Y Li Dan D

Frontiers in endocrinology 20220829

<h4>Objective</h4>To compare the effectiveness of different intrauterine interventions for women with two or more unexplained implantation failures.<h4>Design</h4>A systematic review and network meta-analysis of randomized controlled trials (RCTs).<h4>Patients</h4>Women with two or more implantation failures undergoing fresh or frozen embryo transfer (ET).<h4>Interventions</h4>An electronic search of the following databases: Pubmed, Cochrane Central Register of Controlled Trials (CENTRAL), and E ...[more]

PMID: 36105395

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Dataset Information

Intrauterine interventions for women with two or more implantation failures: A systematic review and network meta-analysis.

Objective

Design

Patients

Interventions

Main outcome measures

Results

Conclusions

Publications

Intrauterine interventions for women with two or more implantation failures: A systematic review and network meta-analysis.

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