Relationship between biomarkers of tubular injury and intrarenal hemodynamic dysfunction in youth with type 1 diabetes.

ABSTRACT:

Background

Early identification of youth with type 1 diabetes (T1D) at risk for diabetic kidney disease may improve clinical outcomes. We examined the cross-sectional relationship between kidney biomarkers neutrophil gelatinase-associated lipocalin (NGAL), copeptin, interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), chitinase-3-like protein-1 (YKL-40), and monocyte chemoattractant protein-1 (MCP-1) and intrarenal hemodynamic function in adolescents with T1D.

Methods

Urine albumin-to-creatinine ratio (UACR), renal vascular resistance (RVR), glomerular filtration rate (GFR), intraglomerular pressure (P_GLO), efferent arteriole resistance (R_E), afferent arteriolar resistance (R_A), and renal plasma flow (RPF), and the above indicated biomar

SUBMITTER: Johnson MJ 

PROVIDER: S-EPMC9470783 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature