Identification of CD8+ T cell subsets that normalize in early-treated people living with HIV receiving antiretroviral therapy

ABSTRACT:

Background

Although combined antiretroviral therapy (cART) has decreased the mortality associated with HIV infection, complete immune reconstitution is not achieved despite viral suppression. Alterations of CD8+ T cells and some of their subpopulations, such as interleukin (IL)-17-producing cells, are evidenced in treated individuals and are associated with systemic inflammation and adverse disease outcomes. We sought to evaluate if different CD8+ T cell subsets are differentially normalized during a clinical follow-up of people living with HIV (PLWH) receiving suppressive cART.

Methods

We explored the changes in the frequencies, activation/exhaustion phenotypes (HLA-DR, CD38, PD-1, and TIM-3), and function (total and HIV-specific cells expressing CD107a, perforin, granzy

SUBMITTER: Perdomo-Celis F 

PROVIDER: S-EPMC9476577 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature