Heterogeneity of Cerebral White Matter Lesions and Clinical Correlates in Older Adults.

ABSTRACT:

Background and purpose

Cerebral white matter signal abnormalities (WMSAs) are a significant radiological marker associated with brain and vascular aging. However, understanding their clinical impact is limited because of their pathobiological heterogeneity. We determined whether use of robust reliable automated procedures can distinguish WMSA classes with different clinical consequences.

Methods

Data from generally healthy participants aged >50 years with moderate or greater WMSA were selected from the Human Connectome Project-Aging (n=130). WMSAs were segmented on T1 imaging. Features extracted from WMSA included total and regional volume, number of discontinuous clusters, size of noncontiguous lesion, contrast of lesion intensity relative to surrounding normal appearing ti

SUBMITTER: Jung KH 

PROVIDER: S-EPMC9477514 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature