Investigation of urinary metabolomics in a phase I hookworm vaccine trial in Gabon.
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ABSTRACT:
SUBMITTER: Betouke Ongwe ME
PROVIDER: S-EPMC9512193 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Investigation of urinary metabolomics in a phase I hookworm vaccine trial in Gabon.
Betouke Ongwe Madeleine Eunice ME Mouwenda Yoanne D YD Stam Koen A KA Kremsner Peter G PG Lell Bertrand B Diemert David D Bethony Jeff J Bottazzi Maria E ME Hotez Peter J PJ Leeuwen Remko V RV Grobusch Martin P MP Adegnika Ayola A AA Mayboroda Oleg A OA Yazdanbakhsh Maria M
PloS one 20220926 9
Metabolomics provides a powerful tool to study physiological changes in response to various perturbations such as vaccination. We explored whether metabolomic changes could be seen after vaccination in a phase I trial where Gabonese adults living either in rural or semi-urban areas received the subunit hookworm vaccine candidates (Na-GST-1 and Na-APR-1 (M74) adjuvanted with Alhydrogel plus GLA-AF (n = 24) or the hepatitis B vaccine (n = 8) as control. Urine samples were collected and assayed usi ...[more]
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