Fractionated Proton Radiation Therapy and Hearing Preservation for Vestibular Schwannoma: Preliminary Analysis of a Prospective Phase 2 Clinical Trial.

ABSTRACT:

Background

Local management for vestibular schwannoma (VS) is associated with excellent local control with focus on preserving long-term serviceable hearing. Fractionated proton radiation therapy (FPRT) may be associated with greater hearing preservation because of unique dosimetric properties of proton radiotherapy.

Objective

To investigate hearing preservation rates of FPRT in adults with VS and secondarily assess local control and treatment-related toxicity.

Methods

A prospective, single-arm, phase 2 clinical trial was conducted of patients with VS from 2010 to 2019. All patients had serviceable hearing at baseline and received FPRT to a total dose of 50.4 to 54 Gy relative biological effectiveness (RBE) over 28 to 30 fractions. Serviceable hearing preservation was

SUBMITTER: Saraf A 

PROVIDER: S-EPMC9514734 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature