Consensus subtypes of hepatocellular carcinoma associated with clinical outcomes and genomic phenotypes.

ABSTRACT:

Background and aims

Although many studies revealed transcriptomic subtypes of HCC, concordance of the subtypes are not fully examined. We aim to examine a consensus of transcriptomic subtypes and correlate them with clinical outcomes.

Approach and results

By integrating 16 previously established genomic signatures for HCC subtypes, we identified five clinically and molecularly distinct consensus subtypes. STM (STeM) is characterized by high stem cell features, vascular invasion, and poor prognosis. CIN (Chromosomal INstability) has moderate stem cell features, but high genomic instability and low immune activity. IMH (IMmune High) is characterized by high immune activity. BCM (Beta-Catenin with high Male predominance) is characterized by prominent β-catenin activation, low m

SUBMITTER: Lee SH 

PROVIDER: S-EPMC9519807 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature