T2-high asthma phenotypes across lifespan.

ABSTRACT:

Rationale

In adults, personalised asthma treatment targets patients with type 2 (T2)-high and eosinophilic asthma phenotypes. It is unclear whether such classification is achievable in children.

Objectives

To define T2-high asthma with easily accessible biomarkers and compare resulting phenotypes across all ages.

Methods

In the multicentre clinical All Age Asthma Cohort (ALLIANCE), 1125 participants (n=776 asthmatics, n=349 controls) were recruited and followed for 2 years (1 year in adults). Extensive clinical characterisation (questionnaires, blood differential count, allergy testing, lung function and sputum induction (in adults)) was performed at baseline and follow-ups. Interleukin (IL)-4, IL-5 and IL-13 were measured after stimulation of whole blood with lipopol

SUBMITTER: Maison N 

PROVIDER: S-EPMC9520028 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature