Association of Folic Acid Supplementation in Early Pregnancy with Risk of Gestational Diabetes Mellitus: A Longitudinal Study.

ABSTRACT:

Background

Gestational diabetes mellitus (GDM) may lead to many adverse effects on women and their offspring.

Method

24,429 pregnant women were enrolled during early pregnancy from January 2018 to December 2021. The self-reported intake of folic acid supplements was assessed via a questionnaire. Oral glucose tolerance tests were used for the diagnosis of GDM. The association between intake or not, dose, and duration of folic acid and GDM risk was assessed.

Results

6396 (26.18%) women were diagnosed with GDM. In the univariate models, folic acid was found to be correlated with total GDM risk (OR = 0.82, 95% CI: 0.70~0.95, p = 0.009). After adjusting for potential confounders, the association with total GDM risk was not significant, but the association of folic a

SUBMITTER: Chen H 

PROVIDER: S-EPMC9571572 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature