Immune-infiltrating signature-based classification reveals CD103⁺CD39⁺ T cells associate with colorectal cancer prognosis and response to immunotherapy.

ABSTRACT:

Background

Current stratification systems for tumor prognostic prediction and immunotherapeutic efficacy evaluation are less satisfying in colorectal cancer (CRC). As infiltrating immune cells in tumor microenvironment (TME) played a key role in tumor progression and responses to immune checkpoint blockade (ICB) therapy, we want to construct an immune-related scoring system with detailed immune profiles to stratify CRC patients.

Methods

We developed a scoring system based on immune-related signatures and validated its ability to predict prognosis and immunotherapeutic outcomes in CRC. CD45⁺ cells from CRC patients were sorted to investigate detailed immune profiles of the stratification system using mass cytometry. A single-cell RNA sequencing dataset was used to

SUBMITTER: Luo Y 

PROVIDER: S-EPMC9596778 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature