Risk Factors for Lung Function Decline in Pediatric Asthma under Treatment: A Retrospective, Multicenter, Observational Study.

ABSTRACT:

Background

Childhood asthma is a major risk for low lung function in later adulthood, but what factors in asthma are associated with the poor lung function during childhood is not known.

Objective

To identify clinical factors in children with asthma associated with low or declining lung function during the treatment.

Methods

We enrolled children with asthma who had been treated throughout three age periods, i.e., 6-9, 10-12, and 13-15 years old, at seven specialized hospitals in Japan. Clinical information and lung function measurements were retrieved from the electronic chart systems. To characterize the lung function trajectories during each age period, we evaluated the forced expiratory volume 1 (FEV1) with % predicted values and individual changes by the slope (S)

SUBMITTER: Yamada S 

PROVIDER: S-EPMC9600699 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature