Original Synthesis of a Nucleolipid for Preparation of Vesicular Spherical Nucleic Acids.

ABSTRACT: Spherical nucleic acids (SNAs)-nanostructures, consisting of a nanoparticle core densely functionalized with a shell of short oligonucleotide strands-are a rapidly emerging class of nanoparticle-based therapeutics with unique properties and specific applications as drug and nucleic acid delivery and gene regulation materials. In this contribution, we report on the preparation of hollow SNA nanoconstructs by co-assembly of an originally synthesized nucleolipid-a hybrid biomacromolecule, composed of a lipidic residue, covalently linked to a DNA oligonucleotide strand-with other lipids. The nucleolipid was synthesized via a click chemistry approach employing initiator-free, UV light-induced thiol-ene coupling of appropriately functionalized intermediates, performed in mild conditions u

SUBMITTER: Dimitrov E 

PROVIDER: S-EPMC9609631 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature