Do Nutrients and Nutraceuticals Play a Role in Diabetic Retinopathy? A Systematic Review.

ABSTRACT: Diabetic retinopathy (DR) is a multifactorial neuro-microvascular disease, whose prevalence ranges from 25% to 60% of subjects affected by diabetes mellitus, representing the main cause of legal blindness in adults of industrialized countries. The treatment of advanced stage of DR is based on invasive and expensive therapies, while few strategies are available for the early stage or prevention. The mechanisms underlying DR involve a complex interplay between the detrimental effects of hyperglycemia, dyslipidemia, hypoxia, and oxidative stress, providing several pathways potentially targeted by nutrients and nutraceuticals. In this study, we conducted a systematic review of observational and interventional studies, evaluating the effect of nutrients and/or nutraceuticals on the risk of DR a

SUBMITTER: Milluzzo A 

PROVIDER: S-EPMC9612209 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature