IgA⁺ memory B-cells are significantly increased in patients with asthma and small airway dysfunction.

ABSTRACT:

Background

Comprehensive studies investigated the role of T-cells in asthma which led to personalised treatment options targeting severe eosinophilic asthma. However, little is known about the contribution of B-cells to this chronic inflammatory disease. In this study we investigated the contribution of various B-cell populations to specific clinical features in asthma.

Methods

In the All Age Asthma Cohort (ALLIANCE), a subgroup of 154 adult asthma patients and 28 healthy controls were included for B-cell characterisation by flow cytometry. Questionnaires, lung function measurements, blood differential counts and allergy testing of participants were analysed together with comprehensive data on B-cells using association studies and multivariate linear models.

Results

P

SUBMITTER: Habener A 

PROVIDER: S-EPMC9630610 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature