The influence of 17q21.31 and APOE genetic ancestry on neurodegenerative disease risk.

ABSTRACT: Advances in genomic research over the last two decades have greatly enhanced our knowledge concerning the genetic landscape and pathophysiological processes involved in multiple neurodegenerative diseases. However, current insights arise almost exclusively from studies on individuals of European ancestry. Despite this, studies have revealed that genetic variation differentially impacts risk for, and clinical presentation of neurodegenerative disease in non-European populations, conveying the importance of ancestry in predicting disease risk and understanding the biological mechanisms contributing to neurodegeneration. We review the genetic influence of two important disease-associated loci, 17q21.31 (the "MAPT locus") and APOE, to neurodegenerative disease risk in non-Europea

SUBMITTER: Harerimana NV 

PROVIDER: S-EPMC9632173 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature