A CD8⁺ T cell-associated immune gene panel for prediction of the prognosis and immunotherapeutic effect of melanoma.

ABSTRACT:

Background

Skin cutaneous melanoma (SKCM) is the most frequently encountered tumor of the skin. Immunotherapy has opened a new horizon in melanoma treatment. We aimed to construct a CD8⁺ T cell-associated immune gene prognostic model (CDIGPM) for SKCM and unravel the immunologic features and the benefits of immunotherapy in CDIGPM-defined SKCM groups.

Method

Single-cell SKCM transcriptomes were utilized in conjunction with immune genes for the screening of CD8⁺ T cell-associated immune genes (CDIGs) for succeeding assessment. Thereafter, through protein-protein interaction (PPI) networks analysis, univariate COX analysis, and multivariate Cox analysis, six genes (MX1, RSAD2, IRF2, GBP2, IFITM1, and OAS2) were id

SUBMITTER: Sun S 

PROVIDER: S-EPMC9633226 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature