Cancer risk associated with cytomegalovirus infection among solid organ transplant recipients in the United States.

ABSTRACT:

Background

Cytomegalovirus (CMV) is among the most common viral infections after solid organ transplantation (SOT). Associations of CMV with cancer risk among SOT recipients have been incompletely evaluated.

Methods

The authors used linked data from the US SOT registry and 32 cancer registries. Poisson regression was used to compare cancer incidence across CMV risk groups based on donor (D) and recipient (R) immunoglobulin G (IgG) serostatus: high risk (R-negative/D-positive), moderate risk (R-positive), and low risk (R-negative/D-negative).

Results

In total, 247,318 SOT recipients were evaluated during 2000-2017 (R-negative/D-positive, 20.3%; R-positive, 62.9%; R-negative/D-negative, 16.8%). CMV-seropositive recipients were older, more racially/ethnically diverse, an

SUBMITTER: Geris JM 

PROVIDER: S-EPMC9633408 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature