Perioperative oxidative stress predicts subsequent pain-related outcomes in the 6 months after total knee arthroplasty.

ABSTRACT:

Abstract

Total knee arthroplasty (TKA) is effective for pain reduction in most patients, but 15% or more report unsatisfactory long-term pain outcomes. We tested whether oxidative stress (OS) related to extended tourniquet application during TKA and subsequent ischemic reperfusion (IR) contributed to adverse post-TKA pain outcomes. Blood samples were obtained in 91 patients with osteoarthritis (63% female) undergoing TKA before tourniquet placement (T1), 45 minutes after tourniquet inflation (T2), and 15 minutes after tourniquet removal (T3). Plasma levels of F 2 -isoprostanes and isofurans, the most specific measures of in vivo OS, were quantified. Pain intensity and function were assessed at baseline and again at 6 weeks and 6 months after TKA. Results indicated that higher Combi

SUBMITTER: Bruehl S 

PROVIDER: S-EPMC9633585 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature