Treadmill training in Parkinson's disease is underpinned by the interregional connectivity in cortical-subcortical network.

ABSTRACT: Treadmill training (TT) has been extensively used as an intervention to improve gait and mobility in patients with Parkinson's disease (PD). Regional and global effects on brain activity could be induced through TT. Training effects can lead to a beneficial shift of interregional connectivity towards a physiological range. The current work investigates the effects of TT on brain activity and connectivity during walking and at rest by using both functional near-infrared spectroscopy and functional magnetic resonance imaging. Nineteen PD patients (74.0 ± 6.59 years, 13 males, disease duration 10.45 ± 6.83 years) before and after 6 weeks of TT, along with 19 age-matched healthy controls were assessed. Interregional effective connectivity (EC) between cortical and subcortical regions were asse

SUBMITTER: Ding H 

PROVIDER: S-EPMC9652466 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature